Senior Metabolism Scientist

  • Exton, PA


: $86,260.00 - $140,240.00 /year *

Employment Type

: Full-Time


: Scientific Research

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Position Responsibilities:
Perform in vitro DMPK studies such as intrinsic clearance determination, reaction phenotyping, enzyme inhibition and induction, plasma protein binding
Conduct metabolism studies using various in vitro models. Identify and quantitate metabolites using LC/MS and LC/MS/MS
Operate and maintain LC/MS equipment
Carry out bi-directional transport studies using Caco-2 cells
Prepare written reports for clients upon completion of each task.
Work with Study Directors/Sponsors in study design, protocol preparation, and overseeing conduct of studies
Effectively manage numerous tasks/projects simultaneously to meet internal/external deadlines while maintaining organizational integration within DMPK team
Ensure all laboratory operation and record-keeping are of high quality and compliant with Frontage SOPs or other applicable regulations
Position Requirements:
PhD orMS plus 5 + years relevant industry experience in biochemistry, in vitro DMPK or similar discipline with coursework and research relevant to pharmacokinetics and/or drug metabolism.
Knowledge of LC/MS/MS analytical techniques
Broad post-graduate experience in vitro techniques relevant to DMPK as demonstrated through publications
Significant experience and leadership in enzyme kinetics, enzyme inhibition/induction and in vitro systems used in DMPK research
Knowledge of cell culture and in vitro systems used for bi-directional transport studies is a plus
Associated topics: bioengineering, bioinformatic, biological engineer, biomaterials, biomechanics, biomedical engineer, biosynthetic, enzyme, medical, metabolic

* The salary listed in the header is an estimate based on salary data for similar jobs in the same area. Salary or compensation data found in the job description is accurate.

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